Spontaneous dimer states of the Aβ(21-30) decapeptide.
نویسندگان
چکیده
Constant temperature and replica-exchange molecular dynamics simulations of two Aβ21-30 decapeptides in explicit solvent reveal metastable dimer states that are abundant near physiological temperatures. As Alzheimer's disease is associated with the neurotoxic oligomers of amyloid β-protein, the formation of these dimers provides insight into oligomer assembly.
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عنوان ژورنال:
- Physical chemistry chemical physics : PCCP
دوره 16 26 شماره
صفحات -
تاریخ انتشار 2014